In Vivo Testing Services

Subcutaneous Tumor Models (Xenograft Models)

Field of Application

Xenograft models are the most frequently used test systems for the evaluation of in vivo efficacy of novel anticancer drug candidates. Tumor cells are subcutaneously implanted on the flank of animals, mostly mice or rats, where they proliferate and form measurable tumors. In addition xenograft models are cost-effective.

Our Service

Established and offered tumor models

Tumor Cell Line

Tissue Origin

Species

Info Sheet

HL-60

Blood /Leukemia

Human

KARPAS 299

Blood /Leukemia

Human

MOLM-13

Blood /Leukemia

Human

MV4-11

Blood /Leukemia

Human

SJSA-1

Bone

Human

Human

LN-229

Brain

Human

U-87 MG

Brain

Human

U-118 MG

Brain

Human

Please inquire!

MCF7

Breast

Human

NCI-H292

Lung

Human

Please inquire!

MDA-MB 231

Breast

Human

NCI-H441

Lung

Human

Please inquire!

HeLa

Cervix

Human

Colo-205

Colon

Human

A431

Skin

Human

Please inquire!

HCT-116

Colon

Human

HT29

Colon

Human

LS 174T

Colon

Human

NCI-H1437

Lung

Human

Please inquire!

SW620

Colon

Human

HuTu80

Duodenum

Human

Molt-4

Blood /Leukemia

Human

Please inquire!

A549

Lung

Human

Calu-6

Lung

Human

H460

Lung

Human

HT-144

Skin

Human

Please inquire!

SKOV-3

Ovary

Human

AsPC1

Pancreas

Human

BxPC-3

Pancreas

Human

MiA-PaCa2

Pancreas

Human

LNCaP (Z2)*

Prostate

Human

PC-3

Prostate

Human

A375

Skin

Human

A2058

Skin

Human

HG3

Blood /Leukemia

Human

Please inquire!

COLO-320DM

Colon

Human

Please inquire!

Hs746T

Stomach

Human

MKN-1

Stomach

Human

MKN-45

Stomach

Human

C8161

Skin

Human

Please inquire!

Calu-3

Lung

Human

Please inquire!

Models with Genetically Engineered Cells

#

Tumor Cell Line

Target

Species

Info Sheet

1

MEF-IGF1-Rrep*

IGF1 Receptor

Mouse

2

NIH3T3-ErbB2-Rrep*

ErbB2 Receptor

Mouse

* in vivo selected subpopulation of the corresponding parental cell line

Info in Brief

Animals Used

All studies are performed in mice

Customer Cell Lines

Studies can be performed with cell lines provided by our customers

Reference Cpd

Available for most established cell lines

Standard Study

Comprises among other things: (i) cell culturing & cell implantation; (ii) measurement of animal weight (3x / week); (iii) determination of tumor size (2x / week); (iv) treatment for 3 weeks (1x / day; 5x / week); (v) protocol & report

Sample Report

Will be provided upon request

Optional Services

(i) Blood sampling; (ii) organ sampling; (iii) paraffin embedding of tumor tissue; (iv) histology & pathology

Summary Sheet

PDF