In Vivo Testing Services

Subcutaneous Tumor Models (Xenograft Models & Syngeneic Models)

Field of Application

Xenograft models are the most frequently used test systems for the evaluation of in vivo efficacy of novel anticancer drug candidates. Tumor cells are subcutaneously implanted on the flank of animals, mostly mice or rats, where they proliferate and form measurable tumors. In addition xenograft models are cost-effective.

Our Service

Established and offered tumor models

#

Tumor Cell Line

Tissue Origin

Species

Info Sheet

2

HL-60

Blood /Leukemia

Human

3

KARPAS 299

Blood /Leukemia

Human

4

MOLM-13

Blood /Leukemia

Human

6

MV4-11

Blood /Leukemia

Human

7

SJSA-1

Bone

Human

8

LN-229

Brain

Human

9

U-87 MG

Brain

Human

10

4T1

Breast

Mouse

11

MCF7

Breast

Human

12

MCF7-Z*

Breast

Human

13

MDA-MB 231

Breast

Human

14

HeLa

Cervix

Human

15

Colo-205

Colon

Human

17

CT26 wt

Colon

Mouse

18

HCT-116

Colon

Human

19

HT29

Colon

Human

20

LS 174T

Colon

Human

21

MC38-CEA

Colon

Mouse

22

SW620

Colon

Human

23

HuTu80

Duodenum

Human

24

RENCA

Kidney

Mouse

25

A549

Lung

Human

27

Calu-6

Lung

Human

28

H460

Lung

Human

29

LL/2

Lung

Mouse

34

SKOV-3

Ovary

Human

35

AsPC1

Pancreas

Human

36

BxPC-3

Pancreas

Human

37

MiA-PaCa2

Pancreas

Human

38

LNCaP (Z2)*

Prostate

Human

39

PC-3

Prostate

Human

41

A375

Skin

Human

40

A2058

Skin

Human

42

B16-F10

Skin

Mouse

44

Clone M3

Skin

Mouse

46

Hs746T

Stomach

Human

47

MKN-1

Stomach

Human

48

MKN-45

Stomach

Human

43

C8161

Skin

Human

Please inquire!

26

Calu-3

Lung

Human

Please inquire!

16

COLO-320DM

Colon

Human

Please inquire!

1

HG3

Blood /Leukemia

Human

Please inquire!

45

HT-144

Skin

Human

Please inquire!

5

MOLT-4

Blood /Leukemia

Human

Please inquire!

30

NCI-H1437

Lung

Human

Please inquire!

31

NCI-H292

Lung

Human

Please inquire!

32

NCI-H441

Lung

Human

Please inquire!

Models with Genetically Engineered Cells

#

Tumor Cell Line

Target

Species

Info Sheet

1

MEF-IGF1-Rrep*

IGF1 Receptor

Mouse

2

NIH3T3-ErbB2-Rrep*

ErbB2 Receptor

Mouse

* in vivo selected subpopulation of the corresponding parental cell line

Infos in Brief

Animals Used

All studies are performed in mice

Established Cell Lines

Xenograft models (human cells); syngenic models (mouse cells)

Customer Cell Lines

Studies can be performed with cell lines provided by our customers

Reference Cpd

Available for most established cell lines

Standard Study

Comprises among other things: (i) cell culturing & cell implantation; (ii) measurement of animal weight (3x / week); (iii) determination of tumor size (2x / week); (iv) treatment for 3 weeks (1x / day; 5x / week); (v) protocol & report

Optional Services

(i) Blood sampling; (ii) organ sampling; (iii) paraffin embedding of tumor tissue; (iv) histology & pathology

Summary Sheet

PDF