In Vivo Testing Services

Orthotopic Tumor Models (Xenograft Models & Syngeneic Models)

Field of Application

Orthotopic models are ideally suited to test the anticancer efficacy of new drug candidates. For this type of in vivo models, tumor cells are implanted into their organ of origin. The organ-specific microenvironment induces tumor growth similar to that of the original tumor. For these orthotopic models, luciferase-transduced cell lines are used to allow the assessment of tumor growth via bioluminescence imaging (BLI).

Our Service

Established Cell Lines

#

Tumor Cell Line

Tissue Origin

Species

Info Sheet

1

LN-229

Brain

Human

2

U-87 MG

Brain

Human

3

4T1

Breast

Mouse

6

MDA-MB 231 (Z1)*

Breast

Human

8

CT26 wt

Colon

Mouse

9

HCT-116

Colon

Human

10

RENCA

Kidney

Mouse

11

AsPC1

Pancreas

Human

13

MiA-PaCa2

Pancreas

Human

15

LNCaP (Z2)*

Prostate

Human

16

PC-3

Prostate

Human

17

B16-F10

Skin

Mouse

4

HCC-1569

Breast

Human

Please inquire!

12

BxPC-3

Pancreas

Human

Please inquire!

5

JIMT-1

Breast

Human

Please inquire!

14

Panc02

Pancreas

Mouse

Please inquire!

7

TuBo

Breast

Mouse

Please inquire!

* in vivo selected subpopulation of the corresponding parental cell line

Infos in Brief

Animals Used

All studies are performed in mice

Customer Cell Lines

Orthotopic tumor models can be established with cell lines provided by our customers

Analysis of Tumor Size

Via bioluminescence imaging (BLI) using luciferase-expressing cell lines

Reference Cpd

Available for most established cell lines

Standard Study

Comprises among other things: (i)cell culturing & cell implantation; (ii) measurement of animal weight (3x / week); (iii) determination of tumor size via BLI (1x / week); (v) treatment for 3 weeks (1x / day; 5x / week); (vi) protocol & report

Optional Services

(i) Blood sampling; (ii) organ sampling; (iii) paraffin embedding of tumor/organs; (ii) histology & pathology

Summary Sheet

PDF