Field of Application
Our immune-oncology platform can be used for analysis of immune modulatory drugs as well as for investigation of additional effects of conventional drugs on the immune system. The platform comprises a panel of syngeneic tumor models and established protocols for the analysis of various cell subtypes of the immune system by flow cytometry.
Our Service
Infos in Brief
-
Customer Cell Lines
-
Additional syngeneic tumor models can be established with cell lines provided by our customers
-
Flow Cytometric Analysis
-
Analysis of tumor infiltrating leukocytes and cells isolated from spleen and lymph nodes
Three staining panels established: T cells, MDSCs, Macrophages
Customized staining procedures are possible
-
Tested Checkpoint Inhibitors
-
Anti-PD-L1, anti-PD-1 and anti-CTLA4 antibodies were evaluated in all subcutaneous models
-
Standard Study
-
Comprises among other things:
- Cell culturing & cell implantation;
- Measurement of animal weight (3x / week);
- Determination of tumor size;
Characterization of abundance and relative distribution of different immune cell subsets in the tumor and lymphatic tissues by flow cytometry
-
Optional Services
-
- Blood sampling
- Paraffin embedding of tumor tissue
- Histological & pathological analysis
- Cytokine determination
- Provision of tumor tissue for target validation
In vivo bioluminescence imaging (orthotopic & metastasis models)
-
Summary Sheet
-
Related Publications from ProQinase
-
White Paper (8,5 MB) Poster from AACR meeting 2016, New Orleans