In Vivo Testing Services

Subcutaneous Tumor Models (Xenograft Models & Syngeneic Models)

Field of Application

Subcutaneous tumor models are the most frequently used test systems for the evaluation of in vivo efficacy of novel anticancer drug candidates. For such studies tumor cells are subcutaneously implanted on the flank of animals, mostly mice or rats, where they proliferate and form measurable tumors.

Our Service

Established and offered tumor models

#

Tumor Cell Line

Tissue Origin

Species

Info Sheet

1

HL-60

Blood /Leukemia

Human

2

KARPAS 299

Blood /Leukemia

Human

3

MOLM-13

Blood /Leukemia

Human

4

MV4-11

Blood /Leukemia

Human

5

SJSA-1

Bone

Human

6

LN-229

Brain

Human

7

U-87 MG

Brain

Human

8

4T1

Breast

Mouse

9

MCF7

Breast

Human

10

MCF7-Z*

Breast

Human

11

MDA-MB 231

Breast

Human

12

MDA-MB 231 (Z1)*

Breast

Human

13

HeLa

Cervix

Human

14

Colo-205

Colon

Human

15

CT26 wt

Colon

Mouse

16

HCT-116

Colon

Human

17

HT29

Colon

Human

18

LS 174T

Colon

Mouse

19

MC38-CEA

Colon

Mouse

20

SW620

Colon

Human

21

HuTu80

Duodenum

Human

22

RENCA

Kidney

Mouse

23

A549

Lung

Human

24

Calu-6

Lung

Human

25

H460

Lung

Human

26

LL/2

Lung

Mouse

27

SKOV-3

Ovary

Human

28

AsPC1

Pancreas

Human

29

BxPC-3

Pancreas

Human

30

MiA-PaCa2

Pancreas

Human

31

LNCaP (Z2)*

Prostate

Human

32

PC-3

Prostate

Human

33

A375

Skin

Human

34

A2058

Skin

Human

35

B16-F10

Skin

Mouse

36

Clone M3

Skin

Mouse

37

Hs746T

Stomach

Human

38

MKN-1

Stomach

Human

39

MKN-45

Stomach

Human

Models with Genetically Engineered Cells

#

Tumor Cell Line

Target

Species

Info Sheet

1

MEF-IGF1-Rrep*

IGF1 Receptor

Mouse

2

NIH3T3-ErbB2-Rrep*

ErbB2 Receptor

Mouse

* in vivo selected subpopulation of the corresponding parental cell line

Infos in Brief

Animals Used

All studies are performed in mice

Established Cell Lines

Xenograft models (human cells); syngenic models (mouse cells)

Customer Cell Lines

Studies can be performed with cell lines provided by our customers

Reference Cpd

Available for most established cell lines

Standard Study

Comprises among other things: (i) cell culturing & cell implantation; (ii) measurement of animal weight (3x / week); (iii) determination of tumor size (2x / week); (iv) treatment for 3 weeks (1x / day; 5x / week); (v) protocol & report

Optional Services

(i) Blood sampling; (ii) organ sampling; (iii) paraffin embedding of tumor tissue; (iv) histology & pathology

Summary Sheet

PDF