In vivo Tumor Models


Orthotopic Tumor Models

ProQinase offers orthotopic and metastasizing in vivo tumor models in mice.

 Tissue Origin

Tumor Cell Line

Species

 Blood / Leukemia

Molm-13

Human

 Kidney

RENCA

Mouse

 Pancreas

AsPC-1

Human

MIA PaCa-2

Human

 Prostate

PC-3

Human

LNCaP

Human

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Target-Specific Tumor Models with Genetically Engineered Cells

ProQinase offers target-specific tumor models in mice using cell lines, which were genetically engineered to control the expression of tumor-relevant proteins. Additional cell lines are in preparation, please inquire for detailed information.

 Target

Tumor Cell Line

Species

 IGF1 Receptor

MEF-IGF1-Rrep

Mouse

 ERBB2 Receptor

NIH3T3-ERBB2-Rrep

Mouse

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Subcutaneous Xenograft Tumor Models


ProQinase offers xenograft models with several tumor cell lines that grow as subcutaneous tumors in mice. More cell lines of the NCI panel can easily be established, if they are tumorigenic in mice.

 Tissue Origin

Tumor Cell Line

Species

 Blood / Leukemia

HL-60

 Human

 Karpas-299

 Human

 Molm-13

 Human

 MV4-11

 Human

 Brain

 C6

 Rat

 SK-N-MC

 Human

 Brest

 MCF7

 Human

 MDA-MB-231

 Human

 Cervix

 C33a

 Human

 HeLa

 Human

 Colon

 Colo-205

 Human

 HCT-116

 Human

 HT29

 Human

 LoVo

 Human

 LS 174T

 Human

 RKO

 Human

 SW-620

 Human

 Gastric

 MKN-1

 Human

 MKN-45

 Human

 Kidney

Renca

Mouse

 Liver

 Alexander

  Human 

 Lung

 H460

 Human

 A549

 Human

 H69

 Human

 Calu-6

 Human

 Ovary

 OVCAR-3

 Human

 SKOV-3

 Human

 Pancreas

 AsPC-1

  Human 

 MIA PaCa-2

 Human

 Prostate

 LNCap

 Human

 PC3

 Human

 Skin

 A375

 Human

 A431

 Human

 B16-F10

 Mouse

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Study Design and Readouts

The experimental design of any in vivo tumor study can be tailored to meet our customer's individual requirements. One can choose between dose finding and efficacy studies. Furthermore, the customer can decide on:

  • Route of application: e.g. orally, s.c., i.m., i.p.
  • Scheme of application: from once daily up to continuously
  • Time schedule: e.g. therapy start, study duration
  • Pretreatment period before inoculation of tumor cells
  • Parameters monitored during the study: e.g. animal behavior, tumor size, blood parameters

In addition to standard readouts (animal weight, tumor weight, tumor volume, metastasis pattern) ProQinase offers the following readouts and technologies at study end:

  • Blood parameters (e.g. soluble biomarker [VEGF, soluble VEGFR-2/KDR])
  • Necropsy (collection of more than 40 tissues and organs)
  • Immunohistochemistry (e.g. microvessel density, proliferation and apoptotic indices)
  • Tumor imaging (ultrasound, in vivo bioluminescence imaging)
  • Corrosion casts


Please inquire for a specific quote.

 

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angiogenesis model, orthotopic tumor model, orthotopic tumor models, xenograft tumor model, xenograft tumor models
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