In vivo Tumor and Angiogenesis Models
ProQinase offers in vivo assay services with focus on animal tumor models. Moreover, ProQinase has established a unique in vivo angiogenesis assay with functional human blood vessels in mice.
Spheroid-Based in vivo Angiogenesis Assay
This assay is an innovative method to evaluate small molecule test compounds or antibodies which are directed against a human, endothelial cell-specific target. Orthotopic Tumor Models
ProQinase offers orthotopic and metastasizing in vivo tumor models in mice. Most studies with orthotopically implanted tumors are performed with luciferase transfected tumor cell lines. This allows measurement of tumor growth using bioluminescene in vivo imaging. Moreover, the anti-metastatic potency of test compounds can be quantified by ex-vivo luciferase analysis in a large of panel of organs. Subcutaneous Xenograft Tumor Models
ProQinase offers subcutaneous xenograft tumor models in mice. Target-specific Tumor Models with Genetically Engineered Cells
ProQinase offers target-specific tumor models in mice using cell lines which were genetically engineered to control the expression of tumor-relevant proteins. Study Design and Readouts
ProQinase provides customized protocols, standard readouts and in vivo imaging (bioluminescence and ultrasound).
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