ProQinase's Drug Discovery Products & Services are uniquely designed for drug development targeting protein kinases in cancer and other therapeutic areas. In oncology one particular focus is the performance of angiogenesis assays. Presently the following products and in vitro and in vivo services are available:

• Recombinant Protein Kinases & Substrates:
  164 active, recombinant protein kinases are now available for sale. Prepared in large stocks we are able to deliver the same batch over a long time.
  
  
• In vitro Kinase Assay Services:
  ProQinase offers different types of compound testing in in vitro assays. This includes high throughput screening (HTS) of large compound libraries against one target, or selectivity profiling against several or the full panel of protein kinases (currently 250) which are available at ProQinase. Testing can be performed either as single concentration measurements or as IC₅₀ determinations.
   
  
• Cellular Assay Services:
  ProQinase offers cellular phosphorylation assays and a spheroid-based angiogenesis assay. Testing can be performed in screening mode (using only one or a few concentrations of the test compounds) or as IC₅₀ determination.
  
  
• In vivo Tumor and Angiogenesis Models:
  ProQinase has established a large panel of subcuteanous xenografts and orthotopic in vivo tumor models. Most orthotopic tumor studies are performed with luciferase transfected tumor cell lines allowing bioluminescene imaging. ProQinase's unique spheroid-based in vivo angiogenesis assay allows determination of the anti-angiogenic effect of compounds or antibodies against functional human blood vessels in mice.
  
  
• Clinical Biomarker Analysis:
  ProQinase has established several biomarker assays to determine different biomarker proteins in serum or plasma samples derived from clinical trials.

Individual service packages fitting your individual needs are available on request.